The advent of large-scale sequencing in both development and disease has identified large numbers of candidate genes that may be linked to important phenotypes. Validating the function of these ...

This useful study reports that the exogenous expression of the microRNA miR-195 can partially compensate in early B cell development for the loss of EBF1, one of the key transcription factors in B ...

In this important study, the authors used a zebrafish model and scRNAseq analysis to show that a subset of keratinocytes within melanoma microenvironment highly up-regulate Twist and undergo ...

This important study shows that sound exposure enhances drug delivery to the cochlea via outer hair cell electromotility acting as a "fluid pump". Although others have proposed that electromotility ...

The fusion of two genes on chromosome 12 – NAB2 and STAT6 – has been found in a rare form of cancer, known as a solitary fibrous tumor, which can form in almost any part of the body ( Thway et al., ...

In mammals, autophagosome formation, a central event in autophagy, is initiated by the ULK complex comprising ULK1/2, FIP200, ATG13, and ATG101. However, the structural basis and mechanism of the ULK ...

Live imaging and single-cell sequencing analyses on zebrafish models revealed that noncaloric monosaccharides and glucose similarly induce excessive blood vessel formation due to endothelial cells' ...

A modelling-based analysis reveals a novel type of selectivity for chromatic contrast in a mouse retinal ganglion cell type, and experimental evidence shows that this feature makes this cell type well ...

Psoriasis is a multifactorial immune-mediated inflammatory disease. Its pathogenesis involves abnormal accumulation of neutrophils and T-cell related abnormalities. Pyroptosis is a type of regulated ...

This is an important piece of work that sheds light on our understanding of early lung development. There is solid evidence that there is a key new role for Svep1, which may be acting via FGF9. A more ...

Researchers have identified a set of geological reaction conditions that may have catalysed life on Earth. Researchers have discovered a plausible evolutionary setting in which nucleic acids – the ...

This manuscript provides important new insight into the mechanisms underlying seasonal physiology, using medaka fish as a functional genetic model that naturally exhibits photoperiodic responses. The ...