He suffered the injury in Week 2 against the Chicago Bears and has missed both of the Texans' games since. Head coach DeMeco Ryans has said that Mixon is "day-to-day" but not practicing on Thursday typically is a bad sign for his availability come Sunday.

Running back Joe Mixon and the Houston Texans will go up against the NFL's 30th-ranked run defense when they take on the Buffalo Bills in Week 5. Kickoff is set for 1:00 PM ET on Sunday. Is Mixon worth starting in fantasy this week? Keep reading as we break down his upcoming matchup versus the Bills.

The Houston Texans may be down one of their better players against the Jacksonville Jaguars. Joe Mixon is out for a second straight week with an ankle injury. Cam Akers will draw the start against the Jaguars in Week 4.

The Houston Texans will be without star running back Joe Mixon for their matchup against the Jacksonville Jaguars. Mixon has been dealing with an ankle injury that he suffered during Week 2 against the Chicago Bears.

The Texans’ rushing attack has struggled without Mixon as the feature runner over the past two games. Cam Akers found his way into the end zone against the Minnesota Vikings, but it came through the air on a 6-yard touchdown pass from C.J. Stroud.

Laremy Tunsil is looking "good to go" for the Houston Texans this Sunday against the Buffalo Bills. The four-time Pro Bowl left tackle returned to practice after dealing with an ankle injury on Wednesday.

Joe Mixon's status for Sunday's game against the Buffalo Bills remains a mystery. The Houston Texans Pro Bowl running back once again did not practice because of the lingering ankle injury Thursday in